Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is characterized by menstrual disorders, hyperandrogenism and polycystic ovaries on ultrasonography. This hormonal disorder is also strongly associated with insulin resistance. The diagnosis of PCOS can be established after the exclusion of other causes of mentioned symptoms, such as non-classic congenital adrenal hyperplasia (NCAH). To date, several studies suggest the increased serum concentration of 17-hydroxyprogesterone (17-O...

Introduction: We report a case of CAH who developed several complications due to poor control. Proper diagnosis and treatment can enable men with the disease to have a normal life and fertility. Case report 39-year-old patient with a history of primary adrenal insufficiency was admitted to our department because of infertility. Semen analysis performed prior to hospitalization showed azoospermia. The patient did not have medical documentation regarding his disease and was not ...

Iatrogenic Cushing syndrome caused by the use of steroid medications is common because of the widespread use of these medications for the treatment of many diseases, however development of Cushing syndrome from the topical corticosteroids is very rare in adults.A 45-year-old men (BMI: 44 kg/m2), with a history of psoriasis, developed manifestations of Cushing syndrome, which included weight gain, central obesity, moon face, facial plethora, bu...

Objective: Hypothyroidism is one of the most common disturbances of thyroid function caused by a thyroid hormone deficiency, found predominantly in young women. The general slowdown of metabolic processes and low-grade chronic inflammatory state occurs in the broad spectra of clinical hypothyroidism manifestations. Although several risk factors of hypothyroidism have been identified, the exact pathogenic mechanisms remain unexplained. The conventional treatment of hypothyroidi...

Introduction: Primary hyperparathyroidism (PHPT), as a state of chronic hypercalcemia, can be manifested by non-typical symptoms which can delay the proper diagnosis for many years and lead to serious preventable complications affecting the patient’s quality of life.Case report: A 52-year-old woman with hypertension, thyroid nodular goiter treated with radioactive iodine and a 20-year history of gastric and duodenal ulcerative disease, complicated b...

The accumulated data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and high risk of developing prediabetes and diabetes. The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of insulin resistance and insulin secretion in women with PCOS, comparing to the control group. The study group comprised 43 women with PCOS and 16 controls matc...

Objective: It has been shown that women with PCOS as well as with autoimmune thyroiditis (AIT), are characterized by increased incidence of infertility. Serum anti-Müllerian hormone (AMH), which reflects ovarian reserve, is elevated in PCOS women and is decreased in women with AIT. The Rotterdam criteria recognize four clinical PCOS phenotypes,i.e.,phenotype Acharacterized by clinical and/or biochemical hyperandrogenism (HA), menstrual dysfunction (oligo/amenorrhea) (Olig...

Introduction: Adiponectin is an adipocytokine with insulin-sensitizing and anti-inflammatory properties. In skeletal muscle, it increases fatty acid oxidation and insulin-stimulated glucose uptake through binding with adiponectin receptor 1 (AdipoR1). The aim of our study was to assess the effect of insulin and Intralipid/heparin infusions on muscle AdipoR1 expression in humans.Methods: Twenty healthy male subjects (age 25.2±3.2 years; BMI, 26.5&#17...

Introduction: Glycoprotein 130 (gp130) cytokines, like interleukin 6 (IL6), act through plasma membrane receptors consisting of two glycoproteins: a cytokine binding subunit (like IL6R) and gp130, responsible for signal transduction. IL6 may regulate insulin sensitivity in a dual manner, as both insulin-sensitizing and -desensitizing actions have been reported. Other gp130 cytokines may have a beneficial metabolic effects. The aim of the present study was to assess skeletal mu...

Introduction: Numerous studies indicate an association between low-grade chronic inflammation and predisposition to type 2 diabetes and atherosclerosis. IL18 is a proinflammatory cytokine with proatherogenic properties. Existing evidence indicated that circulating IL18 was associated with insulin resistance, metabolic syndrome and type 2 diabetes. Some data suggest that endogenous IL18 signaling modulates food intake, metabolism and adiposity, as homeostatic regulator. The aim...